PPP6R2

Across TCGA patient cohorts, PPP6R2 mutation is significantly associated with the RNA expression of many other genes, with 2,967 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP6R2-associated genes across cancer lineages are SNUPN, RN7SL237P, and RPL23AP82. Each is linked with PPP6R2 in more than 3 cancer types. Because this analysis shows association rather than direction, both PPP6R2-to-partner and partner-to-PPP6R2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNUPN grouped by PPP6R2-low versus PPP6R2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP6R2→partner) and Y-score (partner→PPP6R2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNUPN →	+0.428	+2.643	<.001	<.001	3	4
LIHC	RN7SL237P →	+0.155	+5.447	<.001	.005	3	3
SKCM	RPL23AP82 →	+0.530	+3.232	.003	.008	3	3
COAD	KIR2DL4 →	+0.751	+3.700	<.001	.001	3	3
COAD	CNOT7 →	+0.506	+3.700	.005	.001	3	3
COAD	PPP2R2A →	+0.518	+3.713	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,967 associations by consensus.

SNUPN by PPP6R2 expression — UCEC

Explore this box plot interactively →