PPP6R2

Across TCGA patient cohorts, PPP6R2 mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP6R2-associated genes across cancer lineages are Caspase-7-cleavedD198, Cyclin-B1, and JNK_pT183_Y185. Each is linked with PPP6R2 in more than 3 cancer types. Because this analysis shows association rather than direction, both PPP6R2-to-partner and partner-to-PPP6R2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PPP6R2-low versus PPP6R2-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP6R2→partner) and Y-score (partner→PPP6R2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Caspase-7-cleavedD198 →	+1.151	+3.169	.001	.019	2	4
UCEC	Cyclin-B1 →	+0.719	+2.807	<.001	<.001	3	3
UCEC	JNK_pT183_Y185 →	-0.142	-1.584	.018	.034	3	3
UCEC	PCNA →	+0.254	+1.584	.001	.019	3	3
COAD	Lck →	+0.362	+3.484	.008	.002	3	3
STAD	FoxM1 →	+0.440	+3.201	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

Caspase-7-cleavedD198 by PPP6R2 expression — STAD

Explore this box plot interactively →