PPP6R2

Across TCGA cell cohorts, PPP6R2 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible PPP6R2-associated genes across cancer lineages are IFNA8, OR2W1, and KIR2DS4. Each is linked with PPP6R2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP6R2-to-partner and partner-to-PPP6R2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNA8 grouped by PPP6R2-low versus PPP6R2-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP6R2→partner) and Y-score (partner→PPP6R2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	IFNA8 →	+0.052	+4.930	<.001	.008	3	1
SOFT_TISSUE	OR2W1 →	+0.023	+5.977	<.001	.001	3	1
SOFT_TISSUE	KIR2DS4 →	+0.078	+4.930	<.001	.008	3	1
PANCREAS	PRSS58 →	+0.092	+5.000	<.001	.006	3	1
LARGE_INTESTINE	C6orf118 →	+0.180	+4.115	<.001	.001	3	1
CNS	IFNA4 →	+0.215	+5.321	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

IFNA8 by PPP6R2 expression — SOFT_TISSUE

Explore this box plot interactively →