PPP6R2

Across TCGA cell cohorts, PPP6R2 mutation is significantly associated with the mutation status of many other genes, with 3,790 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPP6R2-associated genes across cancer lineages are ACSBG1, ERF, and LRFN1. Each is linked with PPP6R2 in more than 3 cancer types. Because this analysis shows association rather than direction, both PPP6R2-to-partner and partner-to-PPP6R2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACSBG1 grouped by PPP6R2-low versus PPP6R2-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP6R2→partner) and Y-score (partner→PPP6R2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ACSBG1 →	+5.115	+5.115	.005	.005	1	4
PANCREAS	ERF →	+5.115	+5.115	.005	.005	1	4
PANCREAS	LRFN1 →	+5.115	+5.115	.005	.005	1	4
BONE	ATXN1 →	+5.584	+5.584	<.001	<.001	1	4
BREAST	SMC3 →	+3.857	+4.807	.002	.002	1	4
BLOOD_Lymphoma	SCRIB →	+3.510	+4.108	.003	.003	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,790 associations by consensus.

ACSBG1 by PPP6R2 expression — PANCREAS

Explore this box plot interactively →