PPP6R1

Across TCGA pan-cancer cohorts, PPP6R1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PPP6R1 data layer compared with 29 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PPP6R1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PPP6R1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

HNSC, LSCC, and LUAD are the cancer types where PPP6R1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.677	0.887	.002	19	view →
LSCC	OS	Quartile	II,III,IV	0.526	1.000	.001	16	view →
LUAD	DFS	Quartile	All	0.950	0.804	.010	5	view →
PDAC	DFS	Median	All	0.893	0.704	.001	4	view →
CCRCC	OS	Tertile	II,III,IV	0.887	0.652	.025	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PPP6R1–HNSC (DFS)

Open the HNSC breakdown →