PPP6R1

Across TCGA patient cohorts, PPP6R1 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP6R1-associated genes across cancer lineages are Annexin-1, ATM, and Caspase-7-cleavedD198. Each is linked with PPP6R1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP6R1-to-partner and partner-to-PPP6R1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by PPP6R1-low versus PPP6R1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP6R1→partner) and Y-score (partner→PPP6R1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.655	+2.434	<.001	.001	3	2
UCEC	ATM →	-0.604	-2.584	<.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.532	+1.505	.007	.034	3	2
UCEC	eIF4E →	+0.154	+3.335	.029	.005	3	1
UCEC	ERK2 →	+0.141	+2.415	.028	.003	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.396	+1.874	.020	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Annexin-1 by PPP6R1 expression — UCEC

Explore this box plot interactively →