PPP6R1

Across TCGA cell cohorts, PPP6R1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,365 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PPP6R1-associated GO terms across cancer lineages are Cytosolic transport, Endosomal transport, and Regulation of calcium ion export across plasma membrane. Each is linked with PPP6R1 in more than 13 cancer types. Because this analysis shows association rather than direction, both PPP6R1-to-partner and partner-to-PPP6R1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cytosolic transport grouped by PPP6R1-low versus PPP6R1-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP6R1→partner) and Y-score (partner→PPP6R1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Cytosolic transport →	+0.066	+0.831	<.001	<.001	3	14
CNS	Endosomal transport →	+0.049	+0.620	<.001	.001	3	13
UPPER_AERODIGESTIVE_TRACT	Regulation of calcium ion export across plasma membrane →	+0.089	+0.855	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Early endosome to Golgi transport →	+0.074	+0.769	.001	<.001	3	13
BONE	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.159	+0.586	.008	.001	3	13
BONE	Phosphatidylinositol biosynthetic process →	+0.047	+0.632	.003	.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,365 associations by consensus.

Cytosolic transport by PPP6R1 expression — SKIN

Explore this box plot interactively →