PPP6R1

Across TCGA cell cohorts, PPP6R1 mutation is significantly associated with the RNA expression of many other genes, with 391 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPP6R1-associated genes across cancer lineages are SOX9, LUZP4, and MUCL3. Each is linked with PPP6R1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP6R1-to-partner and partner-to-PPP6R1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SOX9 grouped by PPP6R1-low versus PPP6R1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP6R1→partner) and Y-score (partner→PPP6R1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SOX9 →	+1.731	+3.212	<.001	.006	3	2
BLOOD_Leukemia	LUZP4 →	+0.391	+4.060	<.001	.003	3	2
BLOOD_Leukemia	MUCL3 →	+0.075	+3.855	<.001	.007	3	2
LARGE_INTESTINE	CNIH1 →	+0.580	+3.299	<.001	.004	3	1
LARGE_INTESTINE	FGF9 →	+1.287	+3.212	.001	.006	3	1
LARGE_INTESTINE	TRIM35 →	+0.575	+3.299	.008	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 391 associations by consensus.

SOX9 by PPP6R1 expression — SKIN

Explore this box plot interactively →