PPP6C

Across TCGA pan-cancer cohorts, PPP6C mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PPP6C data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PPP6C mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PPP6C expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

UCEC, PDAC, and GBM are the cancer types where PPP6C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	1.000	0.904	.007	32	view →
PDAC	OS	Quartile	II,III,IV	0.625	1.000	.001	17	view →
GBM	DFS	Quartile	All	0.604	0.899	.001	14	view →
LSCC	OS	Median	All	0.900	0.724	.013	11	view →
COAD	DFS	Median	IV	0.493	0.944	.031	6	view →
HNSC	OS	Tertile	All	0.318	0.788	.047	4	view →
CCRCC	DFS	Median	II,III,IV	0.988	0.814	.029	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PPP6C–UCEC (OS)

Open the UCEC breakdown →