PPP6C

Across TCGA patient cohorts, PPP6C protein abundance is significantly associated with the RNA expression of many other genes, with 11,833 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible PPP6C-associated genes across cancer lineages are LZIC, DKK3, and CYTH3. Each is linked with PPP6C in more than 4 cancer types. Because this analysis shows association rather than direction, both PPP6C-to-partner and partner-to-PPP6C results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PPP6C versus LZIC in LSCC, with a Pearson correlation of -0.26.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP6C→partner) and Y-score (partner→PPP6C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LZIC →	-0.380	-0.147	.004	.004	3	5
BRCA	DKK3 →	-0.972	-0.206	<.001	.002	3	5
BRCA	CYTH3 →	-0.522	-0.150	<.001	.002	3	5
LSCC	LILRB3 →	+0.690	+0.171	<.001	<.001	3	4
LUAD	SEPTIN14P12 →	+1.018	+0.173	<.001	<.001	3	4
COAD	MMP25 →	+0.448	+0.212	.007	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,833 associations by consensus.

PPP6C vs LZIC — LSCC

Explore this scatter interactively →