PPP5D1

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, PPP5D1 mutation is significantly associated with the total protein of many other genes, with 2 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP5D1-associated genes across cancer lineages are Caspase-7-cleavedD198 and Notch1. Each is linked with PPP5D1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP5D1-to-partner and partner-to-PPP5D1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PPP5D1-low versus PPP5D1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP5D1→partner) and Y-score (partner→PPP5D1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECCaspase-7-cleavedD198 →+1.130+2.827.001.03532
UCECNotch1 →+0.311+2.817<.001.03631
Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

Caspase-7-cleavedD198 by PPP5D1 expression — UCEC

Box plot of Caspase-7-cleavedD198 in PPP5D1-low vs PPP5D1-high samples in UCEC.

Explore this box plot interactively →

Exploration