PPP5D1

Across TCGA cell cohorts, PPP5D1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,595 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible PPP5D1-associated GO terms across cancer lineages are Tubulin deacetylation, Negative regulation of calcium ion export across plasma membrane, and Protein stabilization. Each is linked with PPP5D1 in more than 8 cancer types. Because this analysis shows association rather than direction, both PPP5D1-to-partner and partner-to-PPP5D1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Tubulin deacetylation grouped by PPP5D1-low versus PPP5D1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP5D1→partner) and Y-score (partner→PPP5D1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Tubulin deacetylation →	+0.171	+0.375	<.001	<.001	3	9
LARGE_INTESTINE	Negative regulation of calcium ion export across plasma membrane →	+0.058	+0.214	<.001	.001	3	9
STOMACH	Protein stabilization →	+0.083	+0.531	<.001	.001	3	9
STOMACH	Regulation of macroautophagy →	+0.081	+0.445	<.001	.001	3	9
LUNG_SCLC	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.109	+0.381	.007	.001	3	9
LUNG_SCLC	mRNA transport →	+0.101	+0.443	.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,595 associations by consensus.

Tubulin deacetylation by PPP5D1 expression — BREAST

Explore this box plot interactively →