Across TCGA patient cohorts, PPP4R3C mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP4R3C-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and 14-3-3_beta. Each is linked with PPP4R3C in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP4R3C-to-partner and partner-to-PPP4R3C results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP4R3C→partner) and Y-score (partner→PPP4R3C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.517	-3.000	<.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.580	+1.514	.004	.015	3	2
UCEC	14-3-3_beta →	-0.111	-2.195	.001	.009	3	1
UCEC	eEF2 →	+0.377	+1.514	.001	.015	3	1
UCEC	EGFR_pY1068 →	-0.318	-3.169	<.001	<.001	3	1
UCEC	eIF4E →	+0.182	+2.137	.011	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

Exploration

PPP4R3C survival (RNA) · tumor vs normal (RNA) · all PPP4R3C data types