PPP4R3B

Across TCGA pan-cancer cohorts, PPP4R3B mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PPP4R3B data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PPP4R3B mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PPP4R3B expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

CCRCC, HNSC, and LUAD are the cancer types where PPP4R3B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	III,IV	0.683	1.000	.009	9	view →
HNSC	DFS	Median	All	0.698	1.000	.020	6	view →
LUAD	DFS	Tertile	III,IV	0.794	0.279	.012	6	view →
LSCC	DFS	Tertile	All	0.904	0.474	.036	1	view →
PDAC	OS	Tertile	All	0.930	0.780	.030	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PPP4R3B–CCRCC (DFS)

Open the CCRCC breakdown →