PPP4R3B

Across TCGA patient cohorts, PPP4R3B mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP4R3B-associated genes across cancer lineages are JNK_pT183_Y185, TFRC, and ASNS. Each is linked with PPP4R3B in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP4R3B-to-partner and partner-to-PPP4R3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by PPP4R3B-low versus PPP4R3B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP4R3B→partner) and Y-score (partner→PPP4R3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.176	-1.794	.011	.027	3	2
UCEC	TFRC →	+0.694	+3.000	.001	.001	3	2
UCEC	ASNS →	+0.402	+2.000	.007	.030	3	2
UCEC	ATM →	-0.547	-2.321	.003	.006	3	2
UCEC	Caspase-7-cleavedD198 →	+0.573	+1.894	.019	.030	3	2
BLCA	Bak →	+0.203	+2.820	.030	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

JNK_pT183_Y185 by PPP4R3B expression — UCEC

Explore this box plot interactively →