PPP4R2

Across TCGA pan-cancer cohorts, PPP4R2 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PPP4R2 data layer compared with 28 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher PPP4R2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PPP4R2 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

KIRP, KICH, and STAD are the cancer types where PPP4R2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.161	0.904	<.001	27	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
STAD	OS	Median	All	0.094	0.667	<.001	12	view →
COAD	OS	Median	III,IV	0.159	0.692	.021	12	view →
UCEC	DFS	Median	All	1.000	0.631	.039	8	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
BRCA	OS	Median	All	0.251	0.581	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PPP4R2–KIRP (OS)

Open the KIRP breakdown →