PPP4R2

Across TCGA pan-cancer cohorts, PPP4R2 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PPP4R2 data layer compared with 28 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PPP4R2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PPP4R2 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

HNSC, PDAC, and CCRCC are the cancer types where PPP4R2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.197	1.000	.017	18	view →
PDAC	DFS	Median	IV	0.785	0.214	.006	9	view →
CCRCC	OS	Median	IV	1.000	0.202	.034	4	view →
LUAD	DFS	Quartile	III,IV	0.836	0.418	.033	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PPP4R2–HNSC (OS)

Open the HNSC breakdown →