PPP4R1L

Across TCGA patient cohorts, PPP4R1L mutation is significantly associated with the RNA expression of many other genes, with 4,010 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP4R1L-associated genes across cancer lineages are RN7SL134P, PTCSC2, and YTHDF3-AS1. Each is linked with PPP4R1L in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP4R1L-to-partner and partner-to-PPP4R1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL134P grouped by PPP4R1L-low versus PPP4R1L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP4R1L→partner) and Y-score (partner→PPP4R1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL134P →	+0.096	+2.277	.001	<.001	3	2
COAD	PTCSC2 →	+0.364	+5.602	<.001	.004	3	2
UCEC	YTHDF3-AS1 →	+0.724	+3.032	<.001	<.001	3	1
UCEC	HSPE1-MOB4 →	+0.157	+2.132	<.001	<.001	3	1
UCEC	RPS10-NUDT3 →	+0.194	+2.201	.002	<.001	3	1
UCEC	IGKV1OR2-118 →	+0.152	+2.289	.004	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,010 associations by consensus.

RN7SL134P by PPP4R1L expression — UCEC

Explore this box plot interactively →