PPP4R1L

Across TCGA patient cohorts, PPP4R1L mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP4R1L-associated genes across cancer lineages are 14-3-3_beta, eEF2, and EGFR_pY1068. Each is linked with PPP4R1L in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP4R1L-to-partner and partner-to-PPP4R1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by PPP4R1L-low versus PPP4R1L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP4R1L→partner) and Y-score (partner→PPP4R1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.101	-2.088	.007	.016	3	1
UCEC	eEF2 →	+0.318	+2.999	.017	.035	3	1
UCEC	EGFR_pY1068 →	-0.312	-2.584	<.001	.010	3	1
UCEC	ERK2 →	+0.168	+1.415	.020	.046	3	1
UCEC	FOXO3a →	-0.092	-2.192	.015	.010	3	1
UCEC	GAPDH →	+0.484	+2.115	.016	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

14-3-3_beta by PPP4R1L expression — UCEC

Explore this box plot interactively →