PPP4R1L

Across TCGA cell cohorts, PPP4R1L mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PPP4R1L-associated genes across cancer lineages are KRTAP6-1, EDDM3A, and OTOR. Each is linked with PPP4R1L in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP4R1L-to-partner and partner-to-PPP4R1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP6-1 grouped by PPP4R1L-low versus PPP4R1L-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP4R1L→partner) and Y-score (partner→PPP4R1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	KRTAP6-1 →	+0.060	+5.614	<.001	.002	3	1
SKIN	EDDM3A →	+0.029	+5.415	<.001	.004	3	1
BLOOD_Lymphoma	OTOR →	+0.187	+4.350	<.001	.005	3	1
BLOOD_Lymphoma	KRTAP4-8 →	+0.025	+5.247	<.001	.001	3	1
BLOOD_Lymphoma	KRTAP4-7 →	+0.078	+4.643	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

KRTAP6-1 by PPP4R1L expression — PANCREAS

Explore this box plot interactively →