PPP4R1

Across TCGA pan-cancer cohorts, PPP4R1 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PPP4R1 data layer compared with 25 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher PPP4R1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PPP4R1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUSC show a favorable association.

UVM, UCEC, and CESC are the cancer types where PPP4R1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.136	0.919	<.001	30	view →
UCEC	DFS	Median	All	0.963	0.825	.009	30	view →
CESC	OS	Median	II,III,IV	0.203	0.759	.021	12	view →
ESCA	OS	Median	II,III,IV	0.268	0.706	.001	9	view →
BLCA	DFS	Median	All	0.015	0.594	<.001	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
LUSC	DFS	Median	All	1.000	0.371	.030	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PPP4R1–UVM (OS)

Open the UVM breakdown →