PPP4R1

Across TCGA pan-cancer cohorts, PPP4R1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PPP4R1 data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PPP4R1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PPP4R1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

LUAD, OV, and PDAC are the cancer types where PPP4R1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	0.609	0.922	.003	19	view →
OV	DFS	Tertile	All	0.472	0.891	.007	16	view →
PDAC	OS	Quartile	III,IV	0.212	0.672	.007	10	view →
HNSC	OS	Median	II,III,IV	0.992	0.933	.024	9	view →
UCEC	DFS	Median	II,III,IV	0.936	0.477	.004	4	view →
CCRCC	OS	Quartile	All	0.956	0.764	.019	3	view →
LSCC	OS	Median	All	0.841	0.936	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PPP4R1–LUAD (OS)

Open the LUAD breakdown →