PPP4R1

Across TCGA cell cohorts, PPP4R1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,007 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PPP4R1-associated GO terms across cancer lineages are Regulation of hippo signaling, Sister chromatid segregation, and Negative regulation of macrophage colony-stimulating factor signaling pathway. Each is linked with PPP4R1 in more than 13 cancer types. Because this analysis shows association rather than direction, both PPP4R1-to-partner and partner-to-PPP4R1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of hippo signaling grouped by PPP4R1-low versus PPP4R1-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP4R1→partner) and Y-score (partner→PPP4R1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of hippo signaling →	+0.118	+1.092	<.001	<.001	3	14
BREAST	Sister chromatid segregation →	+0.119	+1.561	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Negative regulation of macrophage colony-stimulating factor signaling pathway →	+0.201	+1.098	.002	.006	3	14
BREAST	Mitotic nuclear division →	+0.118	+1.595	<.001	<.001	3	14
BREAST	Regulation of cell cycle checkpoint →	+0.109	+1.265	<.001	.001	3	14
BREAST	Positive regulation of cell cycle checkpoint →	+0.156	+1.327	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,007 associations by consensus.

Regulation of hippo signaling by PPP4R1 expression — STOMACH

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