PPP4C

Across TCGA pan-cancer cohorts, PPP4C mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PPP4C data layer compared with 25 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PPP4C mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PPP4C expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

COAD, LUAD, and CCRCC are the cancer types where PPP4C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	All	0.875	1.000	.007	78	view →
LUAD	OS	Median	II,III,IV	0.329	0.913	.001	27	view →
CCRCC	DFS	Median	II,III,IV	0.840	0.611	.028	9	view →
PDAC	OS	Quartile	All	0.705	0.972	.015	9	view →
GBM	OS	Median	All	0.895	0.652	.028	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PPP4C–COAD (DFS)

Open the COAD breakdown →