PPP4C

Across TCGA pan-cancer cohorts, PPP4C mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of PPP4C’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where PPP4C mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types PPP4C is over-expressed in tumor.

LSCC, CCRCC, and LUAD are the cancer types where PPP4C tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPP4C mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	All	III,IV	+0.260	<.001	9	view →
CCRCC	Male	All	+0.183	<.001	9	view →
LUAD	Male	II,III,IV	+0.197	<.001	7	view →
HNSC	All	II,III,IV	+0.158	<.001	6	view →
PDAC	All	III,IV	+0.177	.002	3	view →
COAD	Female	All	+0.104	.016	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

PPP4C–LSCC

Open the LSCC breakdown →