PPP4C

Across TCGA patient cohorts, PPP4C mutation is significantly associated with the immune_cell of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP4C-associated genes across cancer lineages are Adipocytes, Erythrocytes, and mv Endothelial cells. Each is linked with PPP4C in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP4C-to-partner and partner-to-PPP4C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Adipocytes grouped by PPP4C-low versus PPP4C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP4C→partner) and Y-score (partner→PPP4C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Adipocytes →	+0.023	+2.301	<.001	.001	3	1
UCEC	Erythrocytes →	+0.022	+2.656	.024	.005	3	1
UCEC	mv Endothelial cells →	-0.023	-3.000	.014	.036	3	1
UCEC	Myocytes →	+0.028	+3.076	.029	.016	3	1
UCEC	Th2 cells →	+0.155	+2.180	.028	.034	3	1
UCEC	Endothelial cells →	-0.040	-1.957	.006	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Adipocytes by PPP4C expression — UCEC

Explore this box plot interactively →