PPP4C

Across TCGA cell cohorts, PPP4C RNA expression is significantly associated with the go_rna of many other GO terms, with 3,968 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PPP4C-associated GO terms across cancer lineages are Positive regulation of intracellular estrogen receptor signaling pathway, Interleukin-34-mediated signaling pathway, and Negative regulation of protein localization to chromatin. Each is linked with PPP4C in more than 12 cancer types. Because this analysis shows association rather than direction, both PPP4C-to-partner and partner-to-PPP4C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of intracellular estrogen receptor signaling pathway grouped by PPP4C-low versus PPP4C-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP4C→partner) and Y-score (partner→PPP4C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of intracellular estrogen receptor signaling pathway →	+0.151	+0.767	<.001	<.001	3	13
OVARY	Interleukin-34-mediated signaling pathway →	+0.217	+0.613	<.001	<.001	3	13
SOFT_TISSUE	Negative regulation of protein localization to chromatin →	+0.103	+0.569	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.166	+0.701	<.001	.003	3	13
OVARY	Positive regulation of macrophage proliferation →	+0.187	+0.519	<.001	.003	3	13
BREAST	Regulation of macrophage proliferation →	+0.198	+0.910	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,968 associations by consensus.

Positive regulation of intracellular estrogen receptor signaling pathway by PPP4C expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →