Across TCGA pan-cancer cohorts, PPP3R1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PPP3R1 data layer compared with 22 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PPP3R1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PPP3R1 expression acts as an unfavorable survival marker.

UCEC, KIRP, and MESO are the cancer types where PPP3R1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	III,IV	0.061	0.588	.018	18	view →
KIRP	OS	Median	All	0.270	0.904	<.001	12	view →
MESO	OS	Median	II,III,IV	0.180	0.560	.046	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: PPP3R1 tumor-vs-normal RNA expression · all PPP3R1 data types