Across TCGA patient cohorts, PPP3R1 protein abundance is significantly associated with the RNA expression of many other genes, with 8,401 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PPP3R1-associated genes across cancer lineages are PPP3CA, PLPP7, and SGIP1. Each is linked with PPP3R1 in more than 4 cancer types. Because this analysis shows association rather than direction, both PPP3R1-to-partner and partner-to-PPP3R1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP3R1→partner) and Y-score (partner→PPP3R1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PPP3CA →	+1.437	+0.559	<.001	<.001	3	5
GBM	PLPP7 →	+0.656	+0.542	<.001	.005	3	5
LSCC	SGIP1 →	+0.984	+0.407	<.001	<.001	3	4
LSCC	SPRED1 →	+0.430	+0.316	.001	.001	3	4
BRCA	ETV1 →	+0.920	+0.411	<.001	.001	3	4
PDAC	FCGR3B →	-1.572	-1.089	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,401 associations by consensus.

Exploration

PPP3R1 survival (RNA) · tumor vs normal (RNA) · all PPP3R1 data types