PPP3CC

Across TCGA pan-cancer cohorts, PPP3CC mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PPP3CC data layer compared with 27 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PPP3CC mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PPP3CC expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

CCRCC, GBM, and HNSC are the cancer types where PPP3CC mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	III,IV	0.757	0.302	.003	23	view →
GBM	DFS	Median	All	0.782	0.651	.003	15	view →
HNSC	DFS	Tertile	All	0.894	0.993	.023	4	view →
UCEC	OS	Median	All	0.968	0.854	.027	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PPP3CC–CCRCC (DFS)

Open the CCRCC breakdown →