PPP3CC

Across TCGA patient cohorts, PPP3CC mutation is significantly associated with the RNA expression of many other genes, with 1,176 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP3CC-associated genes across cancer lineages are RNA5SP256, AGGF1P9, and RN7SL841P. Each is linked with PPP3CC in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP3CC-to-partner and partner-to-PPP3CC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP256 grouped by PPP3CC-low versus PPP3CC-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP3CC→partner) and Y-score (partner→PPP3CC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNA5SP256 →	+0.615	+4.973	<.001	.009	3	2
COAD	AGGF1P9 →	+0.123	+5.251	<.001	.003	3	2
CESC	RN7SL841P →	+0.249	+5.010	<.001	.009	3	1
CESC	ANKRD49P3 →	+0.080	+5.103	<.001	.008	3	1
CESC	RNU7-20P →	+0.625	+5.306	.001	.006	3	1
CESC	JCHAINP1 →	+0.542	+5.010	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,176 associations by consensus.

RNA5SP256 by PPP3CC expression — BLCA

Explore this box plot interactively →