PPP3CC

Across TCGA cell cohorts, PPP3CC mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPP3CC-associated genes across cancer lineages are ESX1, ZNF831, and PZP. Each is linked with PPP3CC in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP3CC-to-partner and partner-to-PPP3CC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ESX1 grouped by PPP3CC-low versus PPP3CC-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP3CC→partner) and Y-score (partner→PPP3CC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ESX1 →	+0.022	+4.467	.001	.004	3	1
LARGE_INTESTINE	ZNF831 →	+0.018	+4.273	<.001	.006	3	1
LARGE_INTESTINE	PZP →	+0.028	+4.467	<.001	.004	3	1
LARGE_INTESTINE	TAFA1 →	+0.410	+4.273	<.001	.006	3	1
LARGE_INTESTINE	CENPVL1 →	+0.227	+4.095	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

ESX1 by PPP3CC expression — LARGE_INTESTINE

Explore this box plot interactively →