PPP3CC

Across TCGA cell cohorts, PPP3CC mutation is significantly associated with the mutation status of many other genes, with 3,008 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPP3CC-associated genes across cancer lineages are IPO11, MMP2, and EDEM2. Each is linked with PPP3CC in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP3CC-to-partner and partner-to-PPP3CC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IPO11 grouped by PPP3CC-low versus PPP3CC-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP3CC→partner) and Y-score (partner→PPP3CC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IPO11 →	+3.313	+3.430	.005	.005	1	2
BLOOD_Leukemia	MMP2 →	+5.050	+4.000	.008	.008	1	2
BLOOD_Leukemia	EDEM2 →	+3.635	+3.635	.003	.003	1	2
BLOOD_Leukemia	DNMT3B →	+4.635	+6.083	<.001	<.001	1	2
BLOOD_Leukemia	PPP1R13B →	+4.050	+3.870	.002	.002	1	2
BLOOD_Leukemia	XRN2 →	+4.050	+3.870	.002	.002	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,008 associations by consensus.

IPO11 by PPP3CC expression — BLOOD_Leukemia

Explore this box plot interactively →