PPP2R5E

Across TCGA pan-cancer cohorts, PPP2R5E mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of PPP2R5E’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PPP2R5E mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PPP2R5E is over-expressed in tumor, although a few such as COAD and CCRCC show the opposite, repressed pattern.

COAD, LUAD, and PDAC are the cancer types where PPP2R5E tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPP2R5E mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	−0.247	<.001	10	view →
LUAD	Female	II,III,IV	+0.258	<.001	9	view →
PDAC	Male	All	+0.765	<.001	8	view →
HNSC	All	II,III,IV	+0.242	<.001	7	view →
CCRCC	Male	IV	−0.203	.013	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

PPP2R5E–COAD

Open the COAD breakdown →