PPP2R5D

Across TCGA pan-cancer cohorts, PPP2R5D mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PPP2R5D data layer compared with 27 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PPP2R5D mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PPP2R5D expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

PDAC, LUAD, and CCRCC are the cancer types where PPP2R5D mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	IV	0.214	0.785	.006	9	view →
LUAD	OS	Median	III,IV	0.612	0.997	.013	8	view →
CCRCC	DFS	Quartile	II,III,IV	0.286	1.000	.038	7	view →
UCEC	OS	Tertile	III,IV	1.000	0.491	.042	4	view →
HNSC	DFS	Median	II,III,IV	0.969	0.901	.027	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PPP2R5D–PDAC (DFS)

Open the PDAC breakdown →