PPP2R5D

Across TCGA pan-cancer cohorts, PPP2R5D mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of PPP2R5D’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where PPP2R5D mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types PPP2R5D is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

CCRCC, COAD, and PDAC are the cancer types where PPP2R5D tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPP2R5D mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	III,IV	+0.372	<.001	11	view →
COAD	Male	III,IV	−0.253	<.001	11	view →
PDAC	Male	All	+0.606	<.001	7	view →
LUAD	Male	III,IV	−0.113	.015	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

PPP2R5D–CCRCC

Open the CCRCC breakdown →