PPP2R5D

Across TCGA patient cohorts, PPP2R5D mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP2R5D-associated genes across cancer lineages are Annexin-1, PDCD4, and Rictor_pT1135. Each is linked with PPP2R5D in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP2R5D-to-partner and partner-to-PPP2R5D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by PPP2R5D-low versus PPP2R5D-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP2R5D→partner) and Y-score (partner→PPP2R5D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	Annexin-1 →	+0.561	+2.999	.033	.035	3	2
UCEC	PDCD4 →	-0.370	-1.584	.045	.036	3	2
UCEC	Rictor_pT1135 →	-0.081	-1.584	.044	.036	3	2
UCEC	Caspase-7-cleavedD198 →	+0.699	+2.604	.002	.005	3	2
BLCA	GSK-3_pS9 →	+0.508	+3.169	.002	.019	3	1
BLCA	GSK-3a-b_pS21_S9 →	+0.389	+3.169	.025	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Annexin-1 by PPP2R5D expression — BLCA

Explore this box plot interactively →