PPP2R5D

Across TCGA cell cohorts, PPP2R5D RNA expression is significantly associated with the go_rna of many other GO terms, with 4,556 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PPP2R5D-associated GO terms across cancer lineages are DNA replication, Regulation of anaphase-promoting complex-dependent catabolic process, and Mitotic spindle elongation. Each is linked with PPP2R5D in more than 16 cancer types. Because this analysis shows association rather than direction, both PPP2R5D-to-partner and partner-to-PPP2R5D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication grouped by PPP2R5D-low versus PPP2R5D-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP2R5D→partner) and Y-score (partner→PPP2R5D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	DNA replication →	+0.103	+1.160	<.001	<.001	3	17
BREAST	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.132	+0.731	.001	.001	3	16
KIDNEY	Mitotic spindle elongation →	+0.226	+1.044	.005	<.001	3	16
BONE	DNA integrity checkpoint signaling →	+0.082	+0.610	.005	.001	3	16
KIDNEY	Mitotic spindle midzone assembly →	+0.226	+1.044	.005	<.001	3	16
LUNG_NSCLC_LUSC	Sister chromatid segregation →	+0.100	+1.196	.002	.003	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,556 associations by consensus.

DNA replication by PPP2R5D expression — PANCREAS

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