PPP2R5D

Across TCGA cell cohorts, PPP2R5D mutation is significantly associated with the RNA expression of many other genes, with 339 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPP2R5D-associated genes across cancer lineages are DEPDC5, MIOX, and SLC25A17. Each is linked with PPP2R5D in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP2R5D-to-partner and partner-to-PPP2R5D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEPDC5 grouped by PPP2R5D-low versus PPP2R5D-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP2R5D→partner) and Y-score (partner→PPP2R5D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DEPDC5 →	+0.708	+3.169	<.001	.009	3	1
LARGE_INTESTINE	MIOX →	+0.306	+3.087	<.001	.006	3	1
LARGE_INTESTINE	SLC25A17 →	+0.703	+3.364	<.001	.002	3	1
LARGE_INTESTINE	L3MBTL2 →	+0.674	+3.364	<.001	.002	3	1
LARGE_INTESTINE	PHF5A →	+0.493	+3.364	.007	.002	3	1
LARGE_INTESTINE	GNPNAT1 →	+0.685	+3.451	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 339 associations by consensus.

DEPDC5 by PPP2R5D expression — LARGE_INTESTINE

Explore this box plot interactively →