PPP2R5C

Across TCGA pan-cancer cohorts, PPP2R5C mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of PPP2R5C’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where PPP2R5C mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types PPP2R5C is over-expressed in tumor, although a few such as CCRCC and OV show the opposite, repressed pattern.

PDAC, CCRCC, and OV are the cancer types where PPP2R5C tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPP2R5C mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	All	III,IV	+0.782	<.001	9	view →
CCRCC	Male	All	−0.096	<.001	7	view →
OV	All	All	−0.500	.018	2	view →
COAD	Male	All	−0.153	.048	1	view →
LSCC	Male	All	+0.065	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

PPP2R5C–PDAC

Open the PDAC breakdown →