PPP2R5B

Across TCGA pan-cancer cohorts, PPP2R5B mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PPP2R5B data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PPP2R5B mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PPP2R5B expression acts as an unfavorable survival marker, although some lineages such as UCEC and CCRCC show a favorable association.

PDAC, GBM, and UCEC are the cancer types where PPP2R5B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	II,III,IV	0.613	0.873	.010	21	view →
GBM	DFS	Quartile	All	0.236	0.523	.017	9	view →
UCEC	DFS	Median	II,III,IV	0.867	0.534	.040	4	view →
LSCC	DFS	Median	II,III,IV	0.559	0.814	.028	3	view →
CCRCC	DFS	Quartile	III,IV	0.777	0.293	.015	2	view →
HNSC	DFS	Median	IV	1.000	0.924	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PPP2R5B–PDAC (DFS)

Open the PDAC breakdown →