PPP2R5B

Across TCGA patient cohorts, PPP2R5B mutation is significantly associated with the RNA expression of many other genes, with 535 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP2R5B-associated genes across cancer lineages are RN7SKP72, PPIAP24, and MIR1256. Each is linked with PPP2R5B in more than 2 cancer types. Because this analysis shows association rather than direction, both PPP2R5B-to-partner and partner-to-PPP2R5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP72 grouped by PPP2R5B-low versus PPP2R5B-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP2R5B→partner) and Y-score (partner→PPP2R5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SKP72 →	+0.053	+3.095	.004	.007	3	3
LUAD	PPIAP24 →	+0.189	+3.514	<.001	.005	3	2
LUSC	MIR1256 →	+0.636	+4.748	<.001	.003	3	2
CESC	MIR4662B →	+0.313	+4.539	<.001	.008	3	2
UCEC	EFNA1 →	-0.821	-2.989	<.001	.001	3	2
UCEC	RPL23AP82 →	+0.469	+3.343	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 535 associations by consensus.

RN7SKP72 by PPP2R5B expression — SKCM

Explore this box plot interactively →