PPP2R5B

Across TCGA patient cohorts, PPP2R5B mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP2R5B-associated genes across cancer lineages are Rad50, EGFR_pY1068, and A-Raf_pS299. Each is linked with PPP2R5B in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP2R5B-to-partner and partner-to-PPP2R5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by PPP2R5B-low versus PPP2R5B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP2R5B→partner) and Y-score (partner→PPP2R5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.364	-2.000	<.001	.032	3	2
UCEC	EGFR_pY1068 →	-0.276	-2.000	.014	.032	3	1
UCEC	A-Raf_pS299 →	-0.181	-2.000	<.001	.032	3	1
UCEC	JNK_pT183_Y185 →	-0.199	-2.687	.008	.006	3	1
UCEC	Ku80 →	+0.294	+3.335	.005	.005	3	1
UCEC	p27_pT157 →	-0.067	-3.420	.010	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Rad50 by PPP2R5B expression — UCEC

Explore this box plot interactively →