PPP2R5B

Across TCGA cell cohorts, PPP2R5B mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. PANCREAS shows the largest number of these associations.

The most reproducible PPP2R5B-associated genes across cancer lineages are PRKACG, PNLIPRP1, and C3orf85. Each is linked with PPP2R5B in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP2R5B-to-partner and partner-to-PPP2R5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRKACG grouped by PPP2R5B-low versus PPP2R5B-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP2R5B→partner) and Y-score (partner→PPP2R5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PRKACG →	+0.006	+5.614	<.001	.002	3	1
PANCREAS	PNLIPRP1 →	+0.035	+5.000	<.001	.006	3	1
PANCREAS	C3orf85 →	+0.178	+5.000	<.001	.006	3	1
PANCREAS	MYH4 →	+0.026	+5.000	<.001	.006	3	1
LARGE_INTESTINE	SLC15A5 →	+0.023	+5.415	<.001	.004	3	1
BLOOD_Lymphoma	FSHB →	+0.008	+4.247	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

PRKACG by PPP2R5B expression — PANCREAS

Explore this box plot interactively →