PPP2R5A

Across TCGA pan-cancer cohorts, PPP2R5A mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PPP2R5A data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PPP2R5A mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PPP2R5A expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

LUAD, PDAC, and HNSC are the cancer types where PPP2R5A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.833	0.571	.020	10	view →
PDAC	OS	Quartile	II,III,IV	0.524	0.266	.024	9	view →
HNSC	DFS	Median	IV	0.328	0.889	.014	2	view →
GBM	DFS	Tertile	All	0.500	0.294	.025	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PPP2R5A–LUAD (OS)

Open the LUAD breakdown →