PPP2R5A

Across TCGA pan-cancer cohorts, PPP2R5A mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of PPP2R5A’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PPP2R5A mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PPP2R5A is over-expressed in tumor, although a few such as COAD and LSCC show the opposite, repressed pattern.

COAD, LSCC, and LUAD are the cancer types where PPP2R5A tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPP2R5A mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	−0.278	<.001	10	view →
LSCC	Female	All	−0.707	<.001	9	view →
LUAD	Male	III,IV	−0.656	<.001	9	view →
HNSC	Male	IV	−0.541	<.001	8	view →
PDAC	Female	II,III,IV	+0.534	<.001	7	view →
OV	All	All	−0.347	.020	2	view →
CCRCC	Male	All	+0.062	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

PPP2R5A–COAD

Open the COAD breakdown →