PPP2R5A

Across TCGA patient cohorts, PPP2R5A protein abundance is significantly associated with the RNA expression of many other genes, with 17,021 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible PPP2R5A-associated genes across cancer lineages are IRF6, MAP3K21, and PEX11A. Each is linked with PPP2R5A in more than 4 cancer types. Because this analysis shows association rather than direction, both PPP2R5A-to-partner and partner-to-PPP2R5A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PPP2R5A versus IRF6 in LSCC, with a Pearson correlation of 0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP2R5A→partner) and Y-score (partner→PPP2R5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	IRF6 →	+0.959	+0.308	<.001	<.001	3	5
OV	MAP3K21 →	+0.735	+0.306	.002	.004	3	5
BRCA	PEX11A →	+0.839	+0.264	<.001	<.001	3	5
BRCA	EDEM3 →	+0.815	+0.366	<.001	<.001	3	4
BRCA	ADIPOR1 →	+0.516	+0.348	<.001	<.001	3	4
BRCA	DHCR24 →	+0.972	+0.362	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,021 associations by consensus.

PPP2R5A vs IRF6 — LSCC

Explore this scatter interactively →