PPP2R5A

Across TCGA patient cohorts, PPP2R5A mutation is significantly associated with the RNA expression of many other genes, with 2,058 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP2R5A-associated genes across cancer lineages are CINP, BNIP1, and EIF2B2. Each is linked with PPP2R5A in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP2R5A-to-partner and partner-to-PPP2R5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CINP grouped by PPP2R5A-low versus PPP2R5A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP2R5A→partner) and Y-score (partner→PPP2R5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CINP →	+0.289	+1.992	<.001	<.001	3	2
UCEC	BNIP1 →	+0.266	+2.638	.005	.005	3	2
UCEC	EIF2B2 →	+0.298	+1.947	.005	.008	3	2
UCEC	SLC17A5 →	+0.441	+2.436	.009	.001	3	2
UCEC	SLC66A2 →	+0.412	+2.939	.001	<.001	3	2
UCEC	EXOSC9 →	+0.356	+1.960	.007	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,058 associations by consensus.

CINP by PPP2R5A expression — UCEC

Explore this box plot interactively →