PPP2R5A

Across TCGA patient cohorts, PPP2R5A mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP2R5A-associated genes across cancer lineages are EGFR_pY1068, Fibronectin, and INPP4B. Each is linked with PPP2R5A in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP2R5A-to-partner and partner-to-PPP2R5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by PPP2R5A-low versus PPP2R5A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP2R5A→partner) and Y-score (partner→PPP2R5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.197	-1.765	.036	.014	3	2
UCEC	Fibronectin →	-0.252	-1.765	.041	.014	3	2
UCEC	INPP4B →	-0.309	-3.459	.010	.005	3	2
UCEC	JNK2 →	+0.304	+3.486	<.001	.002	3	2
UCEC	Notch1 →	+0.158	+1.598	.002	.040	3	2
UCEC	PCNA →	+0.199	+1.700	.013	.042	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

EGFR_pY1068 by PPP2R5A expression — UCEC

Explore this box plot interactively →