PPP2R3C

Across TCGA pan-cancer cohorts, PPP2R3C Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PPP2R3C data layer compared with 23 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher PPP2R3C Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated PPP2R3C expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

KIRP, UCEC, and SKCM are the cancer types where PPP2R3C Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.037	0.920	<.001	24	view →
UCEC	DFS	Median	All	1.000	0.829	.014	22	view →
SKCM	DFS	Median	III,IV	0.179	0.615	.016	18	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PPP2R3C–KIRP (DFS)

Open the KIRP breakdown →